VARIOUS SIMULATIONS ON CYTOSKELETAL COMPONENTS
OLEG POLYAKOV | PRINCETON UNIVERSITY | 2008-2013

These are various simulations that were developed by Oleg Polyakov and Konstantin Doubrovinsky. These simulations were developed to study the interaction dynamics between myosin, actin, and crosslinkers. Most of these simulations were not published, with the excpetion of '2D simulation of Myosin and Actin' which was published in 2010 with Konstantin and Matthias Kaschube.


2D simulation of Myosin and Actin - This describes the dynamics between myosin and actin both in a 2D and a 1D enviroment. We took the interaction of individual myosin molecules with individual actin filaments and built a mean field model of the interaction of their densities. This model was published in 2010.

Actin and Myosin Continuous Binding - This studies the molecular interction of individual myosin molecules and an actin filament. The dynamics are based on actual stochastic binding and unbinding of individual myosin molecules.

Crosslinker Cluster Formation Simulations - This simulation explores how actin can be crosslinked to form structures. The algorithm that connects the actin together through the crosslinkers is optimized to work in near linear time. Using this simulation it is possible to calculate the persistence length of the crosslinked actin filament.

Free Polarized Actin and Myosin - This is a simple simulation to show what happens when you have myosin and polarized actin.

Myosin Actin and Crosslinkers - This is a simple simulation which tries to combine the behaviour of actin myosin and crosslinkers into a complete model for the cytoskeleton.